Fluoride 1992; 25(2):71-76
Reversible fluoride induced fertility impairment in male mice
NJ Chinoy * and E Sequeira
* Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, Gujarat, India
Summary: Sodium fluoride (NaF) fed to adult male albino mice at a dose of 10 mg and 20 mg/kg body weight, caused a significant decrease in sperm county and motility. Scanning electron microscopy and silver nitrte staining showed large numbers of deflagellated spermatozoa, with acrosomal, midpiece and tail abnormalities. The treatment caused loss of fertility rate when normal cycling female mice were mated with treated males. Withdrawal of treatment for a period of 2 months resulted in a significant recovery in sperm count and sperm motility as well as fertility rate.
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